@article {263,
	title = {A Xenon-Based Molecular Sensor Assembled on an MS2 Viral Capsid Scaffold},
	journal = {Journal of the American Chemical Society},
	volume = {132},
	year = {2010},
	note = {J Am Chem Soc589OATimes Cited:20Cited References Count:23},
	month = {May 5},
	pages = {5936-+},
	abstract = {<p>In MRI, anatomical structures are most often differentiated by variations in their bulk magnetic properties. Alternatively, exogenous contrast agents can be attached to chemical moieties that confer affinity to molecular targets; the distribution of such contrast agents can be imaged by magnetic resonance. Xenon-based molecular sensors are molecular imaging agents that rely on the reversible exchange of hyperpolarized xenon between the bulk and a specifically targeted host-guest complex. We have incorporated similar to 125 xenon sensor molecules in the interior of an MS2 viral capsid, conferring multivalency and other properties of the viral capsid to the sensor molecule. The resulting signal amplification facilitates the detection of sensor at 0.7 pM, the lowest to date for any molecular imaging agent used in magnetic resonance. This amplification promises the detection of chemical targets at much lower concentrations than would be possible without the capsid scaffold.</p>
},
	keywords = {nmr},
	isbn = {0002-7863},
	doi = {Doi 10.1021/Ja100319f},
	url = {<Go to ISI>://WOS:000277158500007},
	author = {Meldrum, T. and Seim, K. L. and Bajaj, V. S. and Palaniappan, K. K. and Wu, W. and Francis, M. B. and Wemmer, D. E. and Pines, A.}
}
