@article {267,
	title = {Hyperpolarized xenon NMR and MRI signal amplification by gas extraction},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {106},
	year = {2009},
	note = {P Natl Acad Sci USA503MDTimes Cited:12Cited References Count:33},
	month = {Oct 6},
	pages = {16903-16906},
	abstract = {<p>A method is reported for enhancing the sensitivity of NMR of dissolved xenon by detecting the signal after extraction to the gas phase. We demonstrate hyperpolarized xenon signal amplification by gas extraction (Hyper-SAGE) in both NMR spectra and magnetic resonance images with time-of-flight information. Hyper-SAGE takes advantage of a change in physical phase to increase the density of polarized gas in the detection coil. At equilibrium, the concentration of gas-phase xenon is approximate to 10 times higher than that of the dissolved-phase gas. After extraction the xenon density can be further increased by several orders of magnitude by compression and/or liquefaction. Additionally, being a remote detection technique, the Hyper-SAGE effect is further enhanced in situations where the sample of interest would occupy only a small proportion of the traditional NMR receiver. Coupled with targeted xenon biosensors, Hyper-SAGE offers another path to highly sensitive molecular imaging of specific cell markers by detection of exhaled xenon gas.</p>
},
	keywords = {field},
	isbn = {0027-8424},
	doi = {Doi 10.1073/Pnas.0909147106},
	url = {<Go to ISI>://WOS:000270537500005},
	author = {Zhou, X. and Graziani, D. and Pines, A.}
}
