@article {268, title = {Optical detection of NMR J-spectra at zero magnetic field}, journal = {Journal of Magnetic Resonance}, volume = {199}, year = {2009}, note = {J Magn Reson456YJTimes Cited:19Cited References Count:26}, month = {Jul}, pages = {25-29}, abstract = {

Scalar couplings of the form JI(1) . I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision\" J spectroscopy\" using small samples oil microchip devices for multiplexed Screening, assaying, and sample identification in chemistry and biomedicine. (C) 2009 Elsevier Inc. All rights reserved.

}, keywords = {cells}, isbn = {1090-7807}, doi = {Doi 10.1016/J.Jmr.2009.03.008}, url = {://WOS:000266890300004}, author = {Ledbetter, M. P. and Crawford, C. W. and Pines, A. and Wemmer, D. E. and Knappe, S. and Kitching, J. and Budker, D.} }