@article {3228,
	title = {Indirect Detection of Short-lived Hydride Intermediates of Iridium N-Heterocyclic Carbene Complexes via Chemical Exchange Saturation Transfer (CEST) Spectroscopy},
	journal = {The Journal of Physical Chemistry C},
	year = {2019},
	month = {06/2019},
	abstract = {<p>For the first time, chemical exchange saturation transfer (CEST) nuclear magnetic resonance (NMR) is utilized to study short-lived hydride intermediates in the catalytic cycle of an organometallic complex [Ir(IMes)(Py)3(H)2]Cl. These complexes are typically not observable by other NMR techniques because they are low concentrated and undergo reversible ligand exchange with the main complex. The intermediatecomplexes [Ir(Cl)(IMes)(Py)2(H)2] and [Ir(CD3OD)(IMes)(Py)2(H)2]are detected, assigned, and characterized in solution, in situ and at room temperature. Understanding the spin dynamics in these complexes is necessary for enhancing the performance of the nuclear spin hyperpolarization technique signal amplification by reversible exchange. By eliminating [Ir(Cl (IMes)(Py)2(H)2] and manipulating the spin system by radiofrequency irradiation, the nuclear spin singlet lifetime of the hydride protons was increased by more than an order of magnitude, from 2.2 \&plusmn; 0.1 to 27.2 \&plusmn; 1.2 s. Because of its simplicity and ability to unravel unobservable chemical species, the utilized CEST NMR approach has a large application potential for studying short-lived hydride intermediates incatalytic reactions.</p>
},
	doi = {https://doi.org/10.1021/acs.jpcc.9b04179},
	url = {https://pubs.acs.org/doi/10.1021/acs.jpcc.9b04179$\#$},
	author = {Stephan Knecht and Sara Hadjiali and Danila A Barskiy and Alexander Pines and Grit Sauer and Alexey Kiryutin and Konstantin Ivanov and Alexandra Yurkovskaya and Gerd Buntkowsky}
}
@article {3194,
	title = {SABRE: Chemical kinetics and spin dynamics of the formation of hyperpolarization},
	journal = {Progress in Nuclear Magnetic Resonance Spectroscopy},
	year = {2019},
	month = {05/2019},
	doi = {10.1016/j.pnmrs.2019.05.005},
	url = {https://www.sciencedirect.com/science/article/pii/S007965651930024X},
	author = {Danila Barskiy and Stephan Knecht and Alexandra Yurkovskaya and Konstantin Ivanov}
}
@article {250,
	title = {Measurement of Arterial Input Function in Hyperpolarized C-13 Studies},
	journal = {Applied Magnetic Resonance},
	volume = {43},
	year = {2012},
	note = {Appl Magn Reson974GTTimes Cited:0Cited References Count:16},
	month = {Jul},
	pages = {289-297},
	abstract = {<p>Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study in vivo metabolism. Injection of hyperpolarized [1-C-13] pyruvate, the most widely used substrate, allows detection of time courses of [1-C-13] pyruvate and its metabolic products, such as [1-C-13] lactate and C-13-bicarbonate, in various organs. However, quantitative metabolic modeling of in vivo data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-C-13] pyruvate can be measured in vivo in the rat carotid artery using an implantable coil.</p>
},
	keywords = {kinetics},
	isbn = {0937-9347},
	doi = {Doi 10.1007/S00723-012-0348-3},
	url = {<Go to ISI>://WOS:000306421200024},
	author = {Marjanska, M. and Teisseyre, T. Z. and Halpern-Manners, N. W. and Zhang, Y. and Iltis, I. and Bajaj, V. and Ugurbil, K. and Pines, A. and Henry, P. G.}
}
