@article {294,
	title = {Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor},
	journal = {Science},
	volume = {314},
	year = {2006},
	note = {Science096MWTimes Cited:109Cited References Count:20},
	month = {Oct 20},
	pages = {446-449},
	abstract = {<p>A magnetic resonance approach is presented that enables high-sensitivity, high-contrast molecular imaging by exploiting xenon biosensors. These sensors link xenon atoms to specific biomolecular targets, coupling the high sensitivity of hyperpolarized nuclei with the specificity of biochemical interactions. We demonstrated spatial resolution of a specific target protein in vitro at micromolar concentration, with a readout scheme that reduces the required acquisition time by \&gt;3300-fold relative to direct detection. This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST). Because it is similar to 10,000 times more sensitive than previous CEST methods and other molecular magnetic resonance imaging techniques, it marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.</p>
},
	keywords = {agents},
	isbn = {0036-8075},
	doi = {Doi 10.1126/Science.1131847},
	url = {<Go to ISI>://WOS:000241382500036},
	author = {Schroder, L. and Lowery, T. J. and Hilty, C. and Wemmer, D. E. and Pines, A.}
}
@article {315,
	title = {Microfluidic gas-flow profiling using remote-detection NMR},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {102},
	year = {2005},
	note = {P Natl Acad Sci USA977NZTimes Cited:41Cited References Count:26},
	month = {Oct 18},
	pages = {14960-14963},
	abstract = {<p>We have used nuclear magnetic resonance (NMR) to obtain spatially and temporally resolved profiles of gas flow in microfluidic devices. Remote detection of the NMR signal both overcomes the sensitivity limitation of NMR and enables time-of-flight measurement in addition to spatially resolved imaging. Thus, detailed insight is gained into the effects of flow, diffusion, and mixing in specific geometries. The ability for noninvasive measurement of microfluidic flow, without the introduction of foreign tracer particles, is unique to this approach and is important for the design and operation of microfluidic devices. Although here we demonstrate an application to gas flow, extension to liquids, which have higher density, is implicit.</p>
},
	keywords = {mri},
	isbn = {0027-8424},
	doi = {Doi 10.1073/Pnas.0507566102},
	url = {<Go to ISI>://WOS:000232811800006},
	author = {Hilty, C. and McDonnell, E. E. and Granwehr, J. and Pierce, K. L. and Han, S. I. and Pines, A.}
}
