@article {245, title = {Fundamental Aspects of Parahydrogen Enhanced Low-Field Nuclear Magnetic Resonance}, journal = {Physical Review Letters}, volume = {110}, year = {2013}, note = {Phys Rev Lett113RITimes Cited:0Cited References Count:28}, month = {Mar 26}, pages = {137602}, abstract = {

We report new phenomena in low-field H-1 nuclear magnetic resonance (NMR) spectroscopy using parahydrogen induced polarization (PHIP), enabling determination of chemical shift differences, delta nu, and the scalar coupling constant J. NMR experiments performed with thermal polarization in millitesla magnetic fields do not allow the determination of scalar coupling constants for homonuclear coupled spins in the inverse weak coupling regime (delta nu \< J). We show here that low-field PHIP experiments in the inverse weak coupling regime enable the precise determination of delta nu and J. Furthermore we experimentally prove that observed splittings are related to delta nu in a nonlinear way. Naturally abundant C-13 and Si-29 isotopes lead to heteronuclear J-coupled H-1-multiplet lines with amplitudes significantly enhanced compared to the amplitudes for thermally prepolarized spins. PHIP-enhanced NMR in the millitesla regime allows us to measure characteristic NMR parameters in a single scan using samples containing rare spins in natural abundance. DOI: 10.1103/PhysRevLett.110.137602

}, keywords = {exchange}, isbn = {0031-9007}, doi = {Doi 10.1103/Physrevlett.110.137602}, url = {://WOS:000316685100032}, author = {Colell, J. and Turschmann, P. and Gloggler, S. and Schleker, P. and Theis, T. and Ledbetter, M. and Budker, D. and Pines, A. and Blumich, B. and Appelt, S.} } @article {273, title = {Flow in Porous Metallic Materials: A Magnetic Resonance Imaging Study}, journal = {Journal of Magnetic Resonance Imaging}, volume = {28}, year = {2008}, note = {J Magn Reson Imaging367QCTimes Cited:5Cited References Count:22}, month = {Nov}, pages = {1299-1302}, abstract = {

Purpose: To visualize flow dynamics of analytes inside porous metallic materials with laser-detected magnetic resonance imaging (MRI).Materials and Methods: We examine the flow of nuclear-polarized water in a porous stainless steel cylinder. Laser-detected MRI utilizes a sensitive optical atomic magnetometer as the detector. Imaging was performed in a remote-detection mode: the encoding was conducted in the Earth\&$\#$39;s magnetic field, and detection is conducted downstream of the encoding location. Conventional MRI (7T) was also performed for comparison.Results: Laser-detected MRI clearly showed MR images of water flowing through the sample, whereas conventional MRI provided no image.Conclusion: We demonstrated the viability of laser-detected MRI at low-field for studying porous metallic materials, extending MRI techniques to a new group of systems that is normally not accessible to conventional MRI.

}, keywords = {mri}, isbn = {1053-1807}, doi = {Doi 10.1002/Jmri.21532}, url = {://WOS:000260566100033}, author = {Xu, S. J. and Harel, E. and Michalak, D. J. and Crawford, C. W. and Budker, D. and Pines, A.} } @article {281, title = {Fluid-flow characterization with nuclear spins without magnetic resonance}, journal = {Applied Physics Letters}, volume = {93}, year = {2008}, note = {Appl Phys Lett345DHTimes Cited:2Cited References Count:20}, month = {Sep 1}, abstract = {

A technique for noninvasive monitoring of flow inside metallic enclosures using laser-based atomic magnetometry is introduced. The analyte is labeled via nuclear magnetization by magnets, thereby combining the polarization and encoding steps. No radiofrequency or audiofrequency pulses are involved. We demonstrate detection of flow inside an aluminum pipe with an inner diameter of 4.9 mm that has a constriction with a diameter of 1.6 mm and a length of 6.4 mm. The results agree with a model of spin density and relaxation indicating that our technique allows for fast, quantitative, and noninvasive diagnostics of flow with potential applications discussed below. (c) 2008 American Institute of Physics.

}, keywords = {mri}, isbn = {0003-6951}, doi = {Doi 10.1063/1.2977773}, url = {://WOS:000258975800042}, author = {Crawford, C. W. and Xu, S. J. and Siegel, E. J. and Budker, D. and Pines, A.} } @article {364, title = {Functionalized xenon as a biosensor}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {98}, year = {2001}, note = {P Natl Acad Sci USA472CZTimes Cited:112Cited References Count:29}, month = {Sep 11}, pages = {10654-10657}, abstract = {

The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capitalizes on the enhanced signal-to-noise, spectral simplicity, and chemical-shift sensitivity of laser-polarized xenon to detect specific biomolecules at the level of tens of nanomoles. We present results using xenon \"functionalized\" by a biotin-modified supramolecular cage to detect biotin-avidin binding. This biosensor methodology can be extended to a multiplexing assay for multiple analytes.

}, keywords = {mri}, isbn = {0027-8424}, doi = {Doi 10.1073/Pnas.191368398}, url = {://WOS:000170966800030}, author = {Spence, M. M. and Rubin, S. M. and Dimitrov, I. E. and Ruiz, E. J. and Wemmer, D. E. and Pines, A. and Yao, S. Q. and Tian, F. and Schultz, P. G.} } @article {424, title = {Failed Failure}, journal = {The NMR Newsletter}, year = {1996}, author = {Pines, A.} } @conference {509, title = {Framework ordering in aluminophosphate molecular sieves studied by (27)Al double rotation NMR}, volume = {69}, year = {1991}, month = {1991}, pages = {435-442}, publisher = {Elsevier}, organization = {Elsevier}, author = {Chmelka, B.F. and Wu, Y. and Jelinek, R. and Davis, M.E. and Pines, A.}, editor = {P.A. Jacobs, N.I. Jaeger, L. Kubelkova, and B. Wichterlov} } @article {517, title = {A Fast, Stable Quadrature Phase Generator for Multiple-Pulse Nmr}, journal = {Review of Scientific Instruments}, volume = {61}, year = {1990}, note = {Rev Sci InstrumDc425Times Cited:8Cited References Count:14}, month = {May}, pages = {1474-1479}, isbn = {0034-6748}, doi = {Doi 10.1063/1.1141155}, url = {://WOS:A1990DC42500016}, author = {Shykind, D. N. and Chingas, G. C. and Pines, A. and Shaka, A. J.} } @article {552, title = {Frequency Selective Nmr Pulse Sequences Generated by Iterative Schemes with Multiple Fixed-Points}, journal = {Molecular Physics}, volume = {67}, year = {1989}, note = {Mol PhysAf151Times Cited:3Cited References Count:24}, month = {Jun 20}, pages = {505-516}, isbn = {0026-8976}, doi = {Doi 10.1080/00268978900101251}, url = {://WOS:A1989AF15100003}, author = {Cho, H. and Mueller, K. T. and Shaka, A. J. and Pines, A.} } @article {618, title = {Fixed-Point Theory of Iterative Excitation Schemes in Nmr}, journal = {Journal of Chemical Physics}, volume = {83}, year = {1985}, note = {J Chem PhysAqw58Times Cited:126Cited References Count:72}, pages = {2775-2802}, isbn = {0021-9606}, doi = {Doi 10.1063/1.449228}, url = {://WOS:A1985AQW5800020}, author = {Tycko, R. and Pines, A. and Guckenheimer, J.} } @article {635, title = {Fourier-Transform Pure Nuclear-Quadrupole Resonance by Pulsed Field Cycling}, journal = {Journal of Chemical Physics}, volume = {80}, year = {1984}, note = {J Chem PhysSh432Times Cited:34Cited References Count:23}, pages = {2232-2234}, isbn = {0021-9606}, doi = {Doi 10.1063/1.446915}, url = {://WOS:A1984SH43200068}, author = {Bielecki, A. and Murdoch, J. B. and Weitekamp, D. P. and Zax, D. B. and Zilm, K. W. and Zimmermann, H. and Pines, A.} } @article {684, title = {Fourier-Transform Double-Quantum Nmr in Solids}, journal = {Physical Review Letters}, volume = {37}, year = {1976}, note = {Phys Rev LettBv563Times Cited:139Cited References Count:12}, pages = {43-46}, isbn = {0031-9007}, doi = {Doi 10.1103/Physrevlett.37.43}, url = {://WOS:A1976BV56300013}, author = {Vega, S. and Shattuck, T. W. and Pines, A.} }