@article {244,
	title = {Molecular imaging of cancer cells using a bacteriophage-based (129) xe NMR biosensor.},
	journal = {Angewandte Chemie-International Edition},
	volume = {52},
	year = {2013},
	pages = {4849-4853},
	edition = {2013 Mar 28},
	doi = {10.1002/anie.201300170},
	author = {Palaniappan, K. K. and Ramirez, R.M. and Bajaj, V.S. and Wemmer, D.E. and Pines, A. and Francis, M.B.}
}
@article {261,
	title = {MRI Thermometry Based on Encapsulated Hyperpolarized Xenon},
	journal = {Chemphyschem},
	volume = {11},
	year = {2010},
	note = {Chemphyschem691LFTimes Cited:2Cited References Count:25},
	month = {Nov 15},
	pages = {3529-3533},
	abstract = {<p>A new approach to MRI thermometry using encapsulated hyperpolarized xenon is demonstrated The method is based on the temperature dependent chemical shift of hyperpolarized xenon in a cryptophane-A cage This shift is linear with a slope of 029 ppm degrees C(-1) which is perceptibly higher than the shift of the proton resonance frequency of water (ca 0 01 ppm degrees C(-1)) that is currently used for MRI thermometry Using spectroscopic imaging techniques, we collected temperature maps of a phantom sample that could discriminate by direct NMR detection between temperature differences of 0 1 degrees C at a sensor concentration of 150 mu M Alternatively, the xenon-in-cage chemical shift was determined by indirect detection using saturation transfer techniques (Hyper-CEST) that allow detection of nanomolar agent concentrations Thermometry based on hyperpolarized xenon sensors improves the accuracy of currently available MRI thermometry methods, potentially giving rise to biomedical applications of biosensors functionalized for binding to specific target molecules</p>
},
	keywords = {xe-129},
	isbn = {1439-4235},
	doi = {Doi 10.1002/Cphc.201000507},
	url = {<Go to ISI>://WOS:000285080600023},
	author = {Schilling, F. and Schroder, L. and Palaniappan, K. K. and Zapf, S. and Wemmer, D. E. and Pines, A.}
}
@article {263,
	title = {A Xenon-Based Molecular Sensor Assembled on an MS2 Viral Capsid Scaffold},
	journal = {Journal of the American Chemical Society},
	volume = {132},
	year = {2010},
	note = {J Am Chem Soc589OATimes Cited:20Cited References Count:23},
	month = {May 5},
	pages = {5936-+},
	abstract = {<p>In MRI, anatomical structures are most often differentiated by variations in their bulk magnetic properties. Alternatively, exogenous contrast agents can be attached to chemical moieties that confer affinity to molecular targets; the distribution of such contrast agents can be imaged by magnetic resonance. Xenon-based molecular sensors are molecular imaging agents that rely on the reversible exchange of hyperpolarized xenon between the bulk and a specifically targeted host-guest complex. We have incorporated similar to 125 xenon sensor molecules in the interior of an MS2 viral capsid, conferring multivalency and other properties of the viral capsid to the sensor molecule. The resulting signal amplification facilitates the detection of sensor at 0.7 pM, the lowest to date for any molecular imaging agent used in magnetic resonance. This amplification promises the detection of chemical targets at much lower concentrations than would be possible without the capsid scaffold.</p>
},
	keywords = {nmr},
	isbn = {0002-7863},
	doi = {Doi 10.1021/Ja100319f},
	url = {<Go to ISI>://WOS:000277158500007},
	author = {Meldrum, T. and Seim, K. L. and Bajaj, V. S. and Palaniappan, K. K. and Wu, W. and Francis, M. B. and Wemmer, D. E. and Pines, A.}
}
