@article {248,
	title = {Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange},
	journal = {Journal of the American Chemical Society},
	volume = {134},
	year = {2012},
	note = {J Am Chem Soc909GLTimes Cited:2Cited References Count:40},
	month = {02/2012},
	pages = {3987-3990},
	abstract = {<p>We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP)(1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative para-hydrogen-induced polarization(4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 mu L, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.</p>
},
	keywords = {gas},
	isbn = {0002-7863},
	doi = {Doi 10.1021/Ja2112405},
	url = {<Go to ISI>://WOS:000301550800015},
	author = {Theis, T. and Ledbetter, M. P. and Kervern, G. and Blanchard, J. W. and Ganssle, P. J. and Butler, M. C. and Shin, H. D. and Budker, D. and Pines, A.}
}
@article {253,
	title = {Parahydrogen-enhanced zero-field nuclear magnetic resonance},
	journal = {Nature Physics},
	volume = {7},
	year = {2011},
	note = {Nat Phys786FYTimes Cited:9Cited References Count:31},
	month = {Jul},
	pages = {571-575},
	abstract = {<p>Nuclear magnetic resonance, conventionally detected in magnetic fields of several tesla, is a powerful analytical tool for the determination of molecular identity, structure and function. With the advent of prepolarization methods and detection schemes using atomic magnetometers or superconducting quantum interference devices, interest in NMR in fields comparable to the Earth\&$\#$39;s magnetic field and below (down to zero field) has been revived. Despite the use of superconducting quantum interference devices or atomic magnetometers, low-field NMR typically suffers from low sensitivity compared with conventional high-field NMR. Here we demonstrate direct detection of zero-field NMR signals generated through parahydrogen-induced polarization, enabling high-resolution NMR without the use of any magnets. The sensitivity is sufficient to observe spectra exhibiting (13)C-(1)H scalar nuclear spin-spin couplings (known as J couplings) in compounds with (13)C in natural abundance, without the need for signal averaging. The resulting spectra show distinct features that aid chemical fingerprinting.</p>
},
	keywords = {order},
	isbn = {1745-2473},
	doi = {Doi 10.1038/Nphys1986},
	url = {<Go to ISI>://WOS:000292290000017},
	author = {Theis, T. and Ganssle, P. and Kervern, G. and Knappe, S. and Kitching, J. and Ledbetter, M. P. and Budker, D. and Pines, A.}
}
