@article {254,
	title = {Remotely Detected NMR for the Characterization of Flow and Fast Chromatographic Separations Using Organic Polymer Monoliths},
	journal = {Analytical Chemistry},
	volume = {83},
	year = {2011},
	note = {Anal Chem798ZVTimes Cited:4Cited References Count:35},
	month = {Aug 1},
	pages = {6004-6010},
	abstract = {<p>An application of remotely detected magnetic resonance imaging is demonstrated for the characterization of flow and the detection of fast, small molecule separations within hypercrosslinked polymer monoliths. The hyper-cross-linked monoliths exhibited excellent ruggedness, with a transit time relative standard deviation of less than 2.1\%, even after more than 300 column volumes were pumped through at high pressure and flow. Magnetic resonance imaging enabled high. resolution intensity and velocity-encoded images of mobile phase flow through the monolith. The images confirm that the presence of a polymer monolith within the capillary disrupts the parabolic laminar flow profile that is characteristic of mobile phase flow within an open tube. As a result, the mobile phase and analytes are equally distributed in the radial direction throughout the monolith. Also, in-line monitoring of chromatographic separations of small molecules at high flow rates is shown. The coupling of monolithic chromatography columns and NMR provides both real-time peak detection and chemical shift information for small aromatic molecules. These experiments demonstrate the unique power of magnetic resonance, both direct and remote, in studying chromatographic processes.</p>
},
	keywords = {visualization},
	isbn = {0003-2700},
	doi = {Doi 10.1021/Ac2010108},
	url = {<Go to ISI>://WOS:000293252500029},
	author = {Teisseyre, T. Z. and Urban, J. and Halpern-Manners, N. W. and Chambers, S. D. and Bajaj, V. S. and Svec, F. and Pines, A.}
}
