@article {256, title = {Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry}, journal = {Magnetic Resonance in Medicine}, volume = {66}, year = {2011}, note = {Magn Reson Med799AVTimes Cited:1Cited References Count:23}, month = {Aug}, pages = {605-608}, abstract = {

Laser atomic magnetomeby is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth\&$\#$39;s magnetic field (40 mu T). The measured relaxivity of 9.7 +/- 2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of similar to 10 mu M Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth\&$\#$39;s field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:605-608, 2011. (C) 2011 Wiley-Liss, Inc.

}, keywords = {nmr}, isbn = {0740-3194}, doi = {Doi 10.1002/Mrm.22811}, url = {://WOS:000293256800033}, author = {Michalak, D. J. and Xu, S. J. and Lowery, T. J. and Crawford, C. W. and Ledbetter, M. and Bouchard, L. S. and Wemmer, D. E. and Budker, D. and Pines, A.} } @article {273, title = {Flow in Porous Metallic Materials: A Magnetic Resonance Imaging Study}, journal = {Journal of Magnetic Resonance Imaging}, volume = {28}, year = {2008}, note = {J Magn Reson Imaging367QCTimes Cited:5Cited References Count:22}, month = {Nov}, pages = {1299-1302}, abstract = {

Purpose: To visualize flow dynamics of analytes inside porous metallic materials with laser-detected magnetic resonance imaging (MRI).Materials and Methods: We examine the flow of nuclear-polarized water in a porous stainless steel cylinder. Laser-detected MRI utilizes a sensitive optical atomic magnetometer as the detector. Imaging was performed in a remote-detection mode: the encoding was conducted in the Earth\&$\#$39;s magnetic field, and detection is conducted downstream of the encoding location. Conventional MRI (7T) was also performed for comparison.Results: Laser-detected MRI clearly showed MR images of water flowing through the sample, whereas conventional MRI provided no image.Conclusion: We demonstrated the viability of laser-detected MRI at low-field for studying porous metallic materials, extending MRI techniques to a new group of systems that is normally not accessible to conventional MRI.

}, keywords = {mri}, isbn = {1053-1807}, doi = {Doi 10.1002/Jmri.21532}, url = {://WOS:000260566100033}, author = {Xu, S. J. and Harel, E. and Michalak, D. J. and Crawford, C. W. and Budker, D. and Pines, A.} } @article {281, title = {Fluid-flow characterization with nuclear spins without magnetic resonance}, journal = {Applied Physics Letters}, volume = {93}, year = {2008}, note = {Appl Phys Lett345DHTimes Cited:2Cited References Count:20}, month = {Sep 1}, abstract = {

A technique for noninvasive monitoring of flow inside metallic enclosures using laser-based atomic magnetometry is introduced. The analyte is labeled via nuclear magnetization by magnets, thereby combining the polarization and encoding steps. No radiofrequency or audiofrequency pulses are involved. We demonstrate detection of flow inside an aluminum pipe with an inner diameter of 4.9 mm that has a constriction with a diameter of 1.6 mm and a length of 6.4 mm. The results agree with a model of spin density and relaxation indicating that our technique allows for fast, quantitative, and noninvasive diagnostics of flow with potential applications discussed below. (c) 2008 American Institute of Physics.

}, keywords = {mri}, isbn = {0003-6951}, doi = {Doi 10.1063/1.2977773}, url = {://WOS:000258975800042}, author = {Crawford, C. W. and Xu, S. J. and Siegel, E. J. and Budker, D. and Pines, A.} } @article {292, title = {Magnetic resonance imaging with an optical atomic magnetometer}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {103}, year = {2006}, note = {P Natl Acad Sci USA077NITimes Cited:58Cited References Count:18}, month = {Aug 22}, pages = {12668-12671}, abstract = {

We report an approach for the detection of magnetic resonance imaging without superconducting magnets and cryogenics: optical atomic magnetometry. This technique possesses a high sensitivity independent of the strength of the static magnetic field, extending the applicability of magnetic resonance imaging to low magnetic fields and eliminating imaging artifacts associated with high fields. By coupling with a remote-detection scheme, thereby improving the filling factor of the sample, we obtained time-resolved flow images of water with a temporal resolution of 0.1 s and spatial resolutions of 1.6 mm perpendicular to the flow and 4.5 mm along the flow. Potentially inexpensive, compact, and mobile, our technique provides a viable alternative for MRI detection with substantially enhanced sensitivity and time resolution for various situations where traditional MRI is not optimal.

}, keywords = {gas}, isbn = {0027-8424}, doi = {Doi 10.1073/Pnas.0605396103}, url = {://WOS:000240035900006}, author = {Xu, S. J. and Yashchuk, V. V. and Donaldson, M. H. and Rochester, S. M. and Budker, D. and Pines, A.} }