@article {257,
	title = {Band-selective chemical exchange saturation transfer imaging with hyperpolarized xenon-based molecular sensors},
	journal = {Journal of Magnetic Resonance},
	volume = {213},
	year = {2011},
	note = {J Magn Reson847UKTimes Cited:3Cited References Count:29},
	month = {Dec},
	pages = {14-21},
	abstract = {<p>Molecular imaging based on saturation transfer in exchanging systems is a tool for amplified and chemically specific magnetic resonance imaging. Xenon-based molecular sensors are a promising category of molecular imaging agents in which chemical exchange of dissolved xenon between its bulk and agent-bound phases has been use to achieve sub-picomolar detection sensitivity. Control over the saturation transfer dynamics, particularly when multiple exchanging resonances are present in the spectra, requires saturation fields of limited bandwidth and is generally accomplished by continuous wave irradiation. We demonstrate instead how band-selective saturation sequences based on multiple pulse inversion elements can yield saturation bandwidth tuneable over a wide range, while depositing less RF power in the sample. We show how these sequences can be used in imaging experiments that require spatial-spectral and multispectral saturation. The results should be applicable to all CEST experiments and, in particular, will provide the spectroscopic control required for applications of arrays of xenon chemical sensors in microfluidic chemical analysis devices. (C) 2011 Elsevier Inc. All rights reserved.</p>
},
	keywords = {xe-129},
	isbn = {1090-7807},
	doi = {Doi 10.1016/J.Jmr.2011.06.027},
	url = {<Go to ISI>://WOS:000296997800002},
	author = {Meldrum, T. and Bajaj, V. S. and Wemmer, D. E. and Pines, A.}
}
@article {261,
	title = {MRI Thermometry Based on Encapsulated Hyperpolarized Xenon},
	journal = {Chemphyschem},
	volume = {11},
	year = {2010},
	note = {Chemphyschem691LFTimes Cited:2Cited References Count:25},
	month = {Nov 15},
	pages = {3529-3533},
	abstract = {<p>A new approach to MRI thermometry using encapsulated hyperpolarized xenon is demonstrated The method is based on the temperature dependent chemical shift of hyperpolarized xenon in a cryptophane-A cage This shift is linear with a slope of 029 ppm degrees C(-1) which is perceptibly higher than the shift of the proton resonance frequency of water (ca 0 01 ppm degrees C(-1)) that is currently used for MRI thermometry Using spectroscopic imaging techniques, we collected temperature maps of a phantom sample that could discriminate by direct NMR detection between temperature differences of 0 1 degrees C at a sensor concentration of 150 mu M Alternatively, the xenon-in-cage chemical shift was determined by indirect detection using saturation transfer techniques (Hyper-CEST) that allow detection of nanomolar agent concentrations Thermometry based on hyperpolarized xenon sensors improves the accuracy of currently available MRI thermometry methods, potentially giving rise to biomedical applications of biosensors functionalized for binding to specific target molecules</p>
},
	keywords = {xe-129},
	isbn = {1439-4235},
	doi = {Doi 10.1002/Cphc.201000507},
	url = {<Go to ISI>://WOS:000285080600023},
	author = {Schilling, F. and Schroder, L. and Palaniappan, K. K. and Zapf, S. and Wemmer, D. E. and Pines, A.}
}
