@article {261,
	title = {MRI Thermometry Based on Encapsulated Hyperpolarized Xenon},
	journal = {Chemphyschem},
	volume = {11},
	year = {2010},
	note = {Chemphyschem691LFTimes Cited:2Cited References Count:25},
	month = {Nov 15},
	pages = {3529-3533},
	abstract = {<p>A new approach to MRI thermometry using encapsulated hyperpolarized xenon is demonstrated The method is based on the temperature dependent chemical shift of hyperpolarized xenon in a cryptophane-A cage This shift is linear with a slope of 029 ppm degrees C(-1) which is perceptibly higher than the shift of the proton resonance frequency of water (ca 0 01 ppm degrees C(-1)) that is currently used for MRI thermometry Using spectroscopic imaging techniques, we collected temperature maps of a phantom sample that could discriminate by direct NMR detection between temperature differences of 0 1 degrees C at a sensor concentration of 150 mu M Alternatively, the xenon-in-cage chemical shift was determined by indirect detection using saturation transfer techniques (Hyper-CEST) that allow detection of nanomolar agent concentrations Thermometry based on hyperpolarized xenon sensors improves the accuracy of currently available MRI thermometry methods, potentially giving rise to biomedical applications of biosensors functionalized for binding to specific target molecules</p>
},
	keywords = {xe-129},
	isbn = {1439-4235},
	doi = {Doi 10.1002/Cphc.201000507},
	url = {<Go to ISI>://WOS:000285080600023},
	author = {Schilling, F. and Schroder, L. and Palaniappan, K. K. and Zapf, S. and Wemmer, D. E. and Pines, A.}
}
@article {294,
	title = {Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor},
	journal = {Science},
	volume = {314},
	year = {2006},
	note = {Science096MWTimes Cited:109Cited References Count:20},
	month = {Oct 20},
	pages = {446-449},
	abstract = {<p>A magnetic resonance approach is presented that enables high-sensitivity, high-contrast molecular imaging by exploiting xenon biosensors. These sensors link xenon atoms to specific biomolecular targets, coupling the high sensitivity of hyperpolarized nuclei with the specificity of biochemical interactions. We demonstrated spatial resolution of a specific target protein in vitro at micromolar concentration, with a readout scheme that reduces the required acquisition time by \&gt;3300-fold relative to direct detection. This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST). Because it is similar to 10,000 times more sensitive than previous CEST methods and other molecular magnetic resonance imaging techniques, it marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.</p>
},
	keywords = {agents},
	isbn = {0036-8075},
	doi = {Doi 10.1126/Science.1131847},
	url = {<Go to ISI>://WOS:000241382500036},
	author = {Schroder, L. and Lowery, T. J. and Hilty, C. and Wemmer, D. E. and Pines, A.}
}
