@article {380, title = {NMR and MRI using laser-polarized xenon}, journal = {Spectroscopy}, volume = {14}, year = {1999}, note = {Spectroscopy216AZTimes Cited:19Cited References Count:65}, month = {Jul}, pages = {26-33}, abstract = {

The application of optical pumping methods increases the nuclear spin polarization of noble gases by four to five orders of magnitude. This enormous increase in polarization translates directly into greatly enhanced signals for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Selected experiments devised to exploit this enhanced sensitivity are reviewed, including xenon NMR/MRI studies of biological systems and polarization transfer to molecules in solution and on surfaces.

}, keywords = {liquid xenon}, isbn = {0887-6703}, url = {://WOS:000081419500003}, author = {Song, Y. Q. and Goodson, B. M. and Pines, A.} } @article {396, title = {NMR of supercritical laser-polarized xenon}, journal = {Chemical Physics Letters}, volume = {292}, year = {1998}, note = {Chem Phys Lett112EZTimes Cited:25Cited References Count:35}, month = {Aug 14}, pages = {686-690}, abstract = {

The feasibility of producing supercritical laser-polarized xenon for nuclear magnetic resonance (NMR) investigations was studied. Using a high-pressure capillary tube, a supercritical xenon sample (52 degrees C, 65 atm) was produced with a Xe-129 polarization approximately 140 times the equilibrium value. The polarization was observed to last for hundreds of seconds, in agreement with previous studies. These preliminary results suggest that supercritical laser-polarized xenon may be used as a polarizing solvent for numerous NMR applications. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

}, keywords = {gas}, isbn = {0009-2614}, doi = {Doi 10.1016/S0009-2614(98)00732-5}, url = {://WOS:000075482300049}, author = {Haake, M. and Goodson, B. M. and Laws, D. D. and Brunner, E. and Cyrier, M. C. and Havlin, R. H. and Pines, A.} } @article {433, title = {NMR of laser-polarized xenon in human blood}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {93}, year = {1996}, note = {P Natl Acad Sci USAVt054Times Cited:92Cited References Count:27}, month = {Nov 12}, pages = {12932-12936}, abstract = {

By means of optical pumping with laser light it is possible to enhance the nuclear spin polarization of gaseous xenon by four to five orders of magnitude, The enhanced polarization has allowed advances in nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), including polarization transfer to molecules and imaging of lungs and other void spaces, A critical issue for such applications is the delivery of xenon to the sample while maintaining the polarization, Described herein is an efficient method for the introduction of laser-polarized xenon into systems of biological and medical interest for the purpose of obtaining highly enhanced NMR/MRI signals. Using this method, we have made the first observation of the time-resolved process of xenon penetrating the red blood cells in fresh human blood-the xenon residence time constant in the red blood cells was measured to be 20.4+/-2 ms. The potential of certain biologically compatible solvents for delivery of laser-polarized xenon to tissues for NMR/MRI is discussed in light of their respective relaxation and partitioning properties.

}, keywords = {gas}, isbn = {0027-8424}, doi = {Doi 10.1073/Pnas.93.23.12932}, url = {://WOS:A1996VT05400048}, author = {Bifone, A. and Song, Y. Q. and Seydoux, R. and Taylor, R. E. and Goodson, B. M. and Pietrass, T. and Budinger, T. F. and Navon, G. and Pines, A.} }