@article {248,
	title = {Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange},
	journal = {Journal of the American Chemical Society},
	volume = {134},
	year = {2012},
	note = {J Am Chem Soc909GLTimes Cited:2Cited References Count:40},
	month = {02/2012},
	pages = {3987-3990},
	abstract = {<p>We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP)(1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative para-hydrogen-induced polarization(4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 mu L, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.</p>
},
	keywords = {gas},
	isbn = {0002-7863},
	doi = {Doi 10.1021/Ja2112405},
	url = {<Go to ISI>://WOS:000301550800015},
	author = {Theis, T. and Ledbetter, M. P. and Kervern, G. and Blanchard, J. W. and Ganssle, P. J. and Butler, M. C. and Shin, H. D. and Budker, D. and Pines, A.}
}
@article {279,
	title = {Zero-field remote detection of NMR with a microfabricated atomic magnetometer},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {105},
	year = {2008},
	note = {P Natl Acad Sci USA266XBTimes Cited:37Cited References Count:26},
	month = {Feb 19},
	pages = {2286-2290},
	abstract = {<p>We demonstrate remote detection of nuclear magnetic resonance (NMR) with a microchip sensor consisting of a microfluidic channel and a microfabricated vapor cell (the heart of an atomic magnetometer). Detection occurs at zero magnetic field, which allows operation of the magnetometer in the spin-exchange relaxation-free (SERF) regime and increases the proximity of sensor and sample by eliminating the need for a solenoid to create a leading field. We achieve pulsed NMR linewidths of 26 Hz, limited, we believe, by the residence time and flow dispersion in the encoding region. In a fully optimized system, we estimate that for 1 s of integration, 7 x 10(13) protons in a volume of 1 mm(3), prepolarized in a 10-kG field, can be detected with a signal-to-noise ratio of approximate to 3. This level of sensitivity is competitive with that demonstrated by microcoils in 100-kG magnetic fields, without requiring superconducting magnets.</p>
},
	keywords = {mri},
	isbn = {0027-8424},
	doi = {Doi 10.1073/Pnas.0711505105},
	url = {<Go to ISI>://WOS:000253469900009},
	author = {Ledbetter, M. P. and Savukov, I. M. and Budker, D. and Shah, V. and Knappe, S. and Kitching, J. and Michalak, D. J. and Xu, S. and Pines, A.}
}
