@article {1478, title = {Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip}, journal = {Nature Communication}, volume = {5}, year = {2014}, pages = {3908}, doi = {10.1038/ncomms4908}, author = {Jimenez-Martinez, R. and Kennedy, D. J. and Rosenbluh, M. and Donley, E. A. and Knappe, S. and Seltzer, S. J. and Ring, H. and Bajaj, V.S. and Kitching, J.} } @article {1475, title = {Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer (Cover Article)}, journal = {Angewandte Chemie}, volume = {53}, year = {2014}, month = {09/2014}, pages = {1-6}, doi = {DOI: 10.1002/anie.201403416}, author = {Ganssle, P. J. and Shin, H. D. and Seltzer, S. J. and Bajaj, V.S. and Ledbetter, M. P. and Budker, D. and Knappe, S. and Kitching, J. and Pines, A} } @article {253, title = {Parahydrogen-enhanced zero-field nuclear magnetic resonance}, journal = {Nature Physics}, volume = {7}, year = {2011}, note = {Nat Phys786FYTimes Cited:9Cited References Count:31}, month = {Jul}, pages = {571-575}, abstract = {

Nuclear magnetic resonance, conventionally detected in magnetic fields of several tesla, is a powerful analytical tool for the determination of molecular identity, structure and function. With the advent of prepolarization methods and detection schemes using atomic magnetometers or superconducting quantum interference devices, interest in NMR in fields comparable to the Earth\&$\#$39;s magnetic field and below (down to zero field) has been revived. Despite the use of superconducting quantum interference devices or atomic magnetometers, low-field NMR typically suffers from low sensitivity compared with conventional high-field NMR. Here we demonstrate direct detection of zero-field NMR signals generated through parahydrogen-induced polarization, enabling high-resolution NMR without the use of any magnets. The sensitivity is sufficient to observe spectra exhibiting (13)C-(1)H scalar nuclear spin-spin couplings (known as J couplings) in compounds with (13)C in natural abundance, without the need for signal averaging. The resulting spectra show distinct features that aid chemical fingerprinting.

}, keywords = {order}, isbn = {1745-2473}, doi = {Doi 10.1038/Nphys1986}, url = {://WOS:000292290000017}, author = {Theis, T. and Ganssle, P. and Kervern, G. and Knappe, S. and Kitching, J. and Ledbetter, M. P. and Budker, D. and Pines, A.} } @article {268, title = {Optical detection of NMR J-spectra at zero magnetic field}, journal = {Journal of Magnetic Resonance}, volume = {199}, year = {2009}, note = {J Magn Reson456YJTimes Cited:19Cited References Count:26}, month = {Jul}, pages = {25-29}, abstract = {

Scalar couplings of the form JI(1) . I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision\" J spectroscopy\" using small samples oil microchip devices for multiplexed Screening, assaying, and sample identification in chemistry and biomedicine. (C) 2009 Elsevier Inc. All rights reserved.

}, keywords = {cells}, isbn = {1090-7807}, doi = {Doi 10.1016/J.Jmr.2009.03.008}, url = {://WOS:000266890300004}, author = {Ledbetter, M. P. and Crawford, C. W. and Pines, A. and Wemmer, D. E. and Knappe, S. and Kitching, J. and Budker, D.} } @article {279, title = {Zero-field remote detection of NMR with a microfabricated atomic magnetometer}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {105}, year = {2008}, note = {P Natl Acad Sci USA266XBTimes Cited:37Cited References Count:26}, month = {Feb 19}, pages = {2286-2290}, abstract = {

We demonstrate remote detection of nuclear magnetic resonance (NMR) with a microchip sensor consisting of a microfluidic channel and a microfabricated vapor cell (the heart of an atomic magnetometer). Detection occurs at zero magnetic field, which allows operation of the magnetometer in the spin-exchange relaxation-free (SERF) regime and increases the proximity of sensor and sample by eliminating the need for a solenoid to create a leading field. We achieve pulsed NMR linewidths of 26 Hz, limited, we believe, by the residence time and flow dispersion in the encoding region. In a fully optimized system, we estimate that for 1 s of integration, 7 x 10(13) protons in a volume of 1 mm(3), prepolarized in a 10-kG field, can be detected with a signal-to-noise ratio of approximate to 3. This level of sensitivity is competitive with that demonstrated by microcoils in 100-kG magnetic fields, without requiring superconducting magnets.

}, keywords = {mri}, isbn = {0027-8424}, doi = {Doi 10.1073/Pnas.0711505105}, url = {://WOS:000253469900009}, author = {Ledbetter, M. P. and Savukov, I. M. and Budker, D. and Shah, V. and Knappe, S. and Kitching, J. and Michalak, D. J. and Xu, S. and Pines, A.} }