@article {289, title = {Sensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal}, journal = {Journal of Magnetic Resonance}, volume = {184}, year = {2007}, note = {J Magn Reson127EUTimes Cited:7Cited References Count:18}, month = {Jan}, pages = {72-77}, abstract = {

Hyperpolarized xenon associated with ligand derivatized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to \&$\#$39;remote detection\&$\#$39; described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer and Fourier analysis of the bulk signal as a function of the evolution time. (c) 2006 Elsevier Inc. All rights reserved.

}, keywords = {resonance}, isbn = {1090-7807}, doi = {Doi 10.1016/J.Jmr.2006.09.010}, url = {://WOS:000243568900009}, author = {Garcia, S. and Chavez, L. and Lowery, T. J. and Han, S. I. and Wemmer, D. E. and Pines, A.} } @article {301, title = {Spectrally resolved magnetic resonance imaging of a xenon biosensor}, journal = {Angewandte Chemie-International Edition}, volume = {45}, year = {2006}, note = {Angew Chem Int Edit997CZTimes Cited:48Cited References Count:14}, pages = {70-73}, keywords = {delivery}, isbn = {1433-7851}, doi = {Doi 10.1002/Anie.200502693}, url = {://WOS:000234223900007}, author = {Hilty, C. and Lowery, T. J. and Wemmer, D. E. and Pines, A.} }