@article {263,
	title = {A Xenon-Based Molecular Sensor Assembled on an MS2 Viral Capsid Scaffold},
	journal = {Journal of the American Chemical Society},
	volume = {132},
	year = {2010},
	note = {J Am Chem Soc589OATimes Cited:20Cited References Count:23},
	month = {May 5},
	pages = {5936-+},
	abstract = {<p>In MRI, anatomical structures are most often differentiated by variations in their bulk magnetic properties. Alternatively, exogenous contrast agents can be attached to chemical moieties that confer affinity to molecular targets; the distribution of such contrast agents can be imaged by magnetic resonance. Xenon-based molecular sensors are molecular imaging agents that rely on the reversible exchange of hyperpolarized xenon between the bulk and a specifically targeted host-guest complex. We have incorporated similar to 125 xenon sensor molecules in the interior of an MS2 viral capsid, conferring multivalency and other properties of the viral capsid to the sensor molecule. The resulting signal amplification facilitates the detection of sensor at 0.7 pM, the lowest to date for any molecular imaging agent used in magnetic resonance. This amplification promises the detection of chemical targets at much lower concentrations than would be possible without the capsid scaffold.</p>
},
	keywords = {nmr},
	isbn = {0002-7863},
	doi = {Doi 10.1021/Ja100319f},
	url = {<Go to ISI>://WOS:000277158500007},
	author = {Meldrum, T. and Seim, K. L. and Bajaj, V. S. and Palaniappan, K. K. and Wu, W. and Francis, M. B. and Wemmer, D. E. and Pines, A.}
}
@article {264,
	title = {Xenon-based molecular sensors in lipid suspensions},
	journal = {Journal of Magnetic Resonance},
	volume = {205},
	year = {2010},
	note = {J Magn Reson627SZTimes Cited:8Cited References Count:23},
	month = {Aug},
	pages = {242-246},
	abstract = {<p>There have been many proposals to use xenon-based molecular sensors in biological settings. Fundamental to understanding the properties of these sensors in vivo is characterizing their behavior in lipid environments. We report the investigation of xenon-based molecular sensors in suspensions of lipid vesicles with a size comparable to cells. We detail spectroscopic properties of sensors associated with lipid vesicles as well as those in equilibrium in the surrounding solution. We characterize the dependence of the spectral parameters on temperature, relevant for studies at physiological temperatures. We also demonstrate the ability to perform selective saturation transfer (Hyper-CEST) between sensor, both lipid bound and unbound, and the bulk solution. Lastly, we demonstrate the applicability of saturation transfer in the heterogeneous medium as an imaging modality. (C) 2010 Elsevier Inc. All rights reserved.</p>
},
	keywords = {binding},
	isbn = {1090-7807},
	doi = {Doi 10.1016/J.Jmr.2010.05.005},
	url = {<Go to ISI>://WOS:000280064500008},
	author = {Meldrum, T. and Schroder, L. and Denger, P. and Wemmer, D. E. and Pines, A.}
}
