%0 Journal Article %J Magnetic Resonance in Medicine %D 2011 %T Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry %A Michalak, D. J. %A Xu, S. J. %A Lowery, T. J. %A Crawford, C. W. %A Ledbetter, M. %A Bouchard, L. S. %A Wemmer, D. E. %A Budker, D. %A Pines, A. %K nmr %X

Laser atomic magnetomeby is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 mu T). The measured relaxivity of 9.7 +/- 2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of similar to 10 mu M Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:605-608, 2011. (C) 2011 Wiley-Liss, Inc.

%B Magnetic Resonance in Medicine %V 66 %P 605-608 %8 Aug %@ 0740-3194 %G English %U ://WOS:000293256800033 %N 2 %M WOS:000293256800033 %! Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry %R Doi 10.1002/Mrm.22811