%0 Journal Article %J Journal of Magnetic Resonance %D 2009 %T Optical detection of NMR J-spectra at zero magnetic field %A Ledbetter, M. P. %A Crawford, C. W. %A Pines, A. %A Wemmer, D. E. %A Knappe, S. %A Kitching, J. %A Budker, D. %K cells %X

Scalar couplings of the form JI(1) . I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision" J spectroscopy" using small samples oil microchip devices for multiplexed Screening, assaying, and sample identification in chemistry and biomedicine. (C) 2009 Elsevier Inc. All rights reserved.

%B Journal of Magnetic Resonance %V 199 %P 25-29 %8 Jul %@ 1090-7807 %G English %U ://WOS:000266890300004 %N 1 %M WOS:000266890300004 %! Optical detection of NMR J-spectra at zero magnetic field %R Doi 10.1016/J.Jmr.2009.03.008