%0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 2009 %T Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles %A Bouchard, L. S. %A Anwar, M. S. %A Liu, G. L. %A Hann, B. %A Xie, Z. H. %A Gray, J. W. %A Wang, X. D. %A Pines, A. %A Chen, F. F. %K cancer %X

Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

%B Proceedings of the National Academy of Sciences of the United States of America %V 106 %P 4085-4089 %8 Mar 17 %@ 0027-8424 %G English %U ://WOS:000264278800008 %N 11 %M WOS:000264278800008 %! Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles %R Doi 10.1073/Pnas.0813019106