%0 Journal Article %J Science %D 2001 %T Approach to high-resolution ex situ NMR spectroscopy %A Meriles, C. A. %A Sakellariou, D. %A Heise, H. %A Moule, A. J. %A Pines, A. %K echoes %X

Nuclear magnetic resonance (NMR) experiments are typically performed with samples immersed in a magnet shimmed to high homogeneity. However, there are many circumstances in which it is impractical or undesirable to insert objects or subjects into the bore of a high-field magnet. Here we present a methodology based on an adaptation of nutation echoes that provides resolved spectra in the presence of matched inhomogeneous static and radiofrequency fields, thereby opening the way to high-resolution exsitu NMR, The observation of chemical shifts is regained through the use of multiple-pulse sequences of correlated, composite z-rotation pulses, producing resolved NMR spectra of liquid samples.

%B Science %V 293 %P 82-85 %8 Jul 6 %@ 0036-8075 %G English %U ://WOS:000169780300032 %N 5527 %M WOS:000169780300032 %! Approach to high-resolution ex situ NMR spectroscopy %R Doi 10.1126/Science.1061498