%0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 1997 %T In vivo NMR and MRI using injection delivery of laser-polarized xenon %A Goodson, B. M. %A Song, Y. Q. %A Taylor, R. E. %A Schepkin, V. D. %A Brennan, K. M. %A Chingas, G. C. %A Budinger, T. F. %A Navon, G. %A Pines, A. %K humans %X

Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo Xe-129 NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

%B Proceedings of the National Academy of Sciences of the United States of America %V 94 %P 14725-14729 %8 Dec 23 %@ 0027-8424 %G English %U ://WOS:000071182800090 %N 26 %M WOS:000071182800090 %! In vivo NMR and MRI using injection delivery of laser-polarized xenon %R Doi 10.1073/Pnas.94.26.14725