%0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 1997 %T In vivo NMR and MRI using injection delivery of laser-polarized xenon %A Goodson, B. M. %A Song, Y. Q. %A Taylor, R. E. %A Schepkin, V. D. %A Brennan, K. M. %A Chingas, G. C. %A Budinger, T. F. %A Navon, G. %A Pines, A. %K humans %X

Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo Xe-129 NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

%B Proceedings of the National Academy of Sciences of the United States of America %V 94 %P 14725-14729 %8 Dec 23 %@ 0027-8424 %G English %U ://WOS:000071182800090 %N 26 %M WOS:000071182800090 %! In vivo NMR and MRI using injection delivery of laser-polarized xenon %R Doi 10.1073/Pnas.94.26.14725 %0 Journal Article %J Angewandte Chemie-International Edition in English %D 1997 %T Selective enhancement of NMR signals for alpha-cyclodextrin with laser-polarized xenon %A Song, Y. Q. %A Goodson, B. M. %A Taylor, R. E. %A Laws, D. D. %A Navon, G. %A Pines, A. %K solids %B Angewandte Chemie-International Edition in English %V 36 %P 2368-2370 %8 Nov 14 %@ 0570-0833 %G English %U ://WOS:A1997YH94400025 %N 21 %M WOS:A1997YH94400025 %! Selective enhancement of NMR signals for alpha-cyclodextrin with laser-polarized xenon %R Doi 10.1002/Anie.199723681 %0 Journal Article %J Science %D 1996 %T Enhancement of solution NMR and MRI with laser-polarized xenon %A Navon, G. %A Song, Y. Q. %A Room, T. %A Appelt, S. %A Taylor, R. E. %A Pines, A. %K resonance %X

Optical pumping with laser light can be used to polarize the nuclear spins of gaseous xenon-129. When hyperpolarized xenon-129 is dissolved in liquids, a time-dependent departure of the proton spin polarization from its thermal equilibrium is observed, The variation of the magnetization is an unexpected manifestation of the nuclear Overhauser effect, a consequence of cross-relaxation between the spins of solution protons and dissolved xenon-129. Time-resolved magnetic resonance images of both nuclei in solution show that the proton magnetization is selectively perturbed in regions containing spin-polarized xenon-129. This effect could find use in nuclear magnetic resonance spectroscopy of surfaces and proteins and in magnetic resonance imaging.

%B Science %V 271 %P 1848-1851 %8 Mar 29 %@ 0036-8075 %G English %U ://WOS:A1996UC77800041 %N 5257 %M WOS:A1996UC77800041 %! Enhancement of solution NMR and MRI with laser-polarized xenon %R Doi 10.1126/Science.271.5257.1848 %0 Journal Article %J Proceedings of the National Academy of Sciences of the United States of America %D 1996 %T NMR of laser-polarized xenon in human blood %A Bifone, A. %A Song, Y. Q. %A Seydoux, R. %A Taylor, R. E. %A Goodson, B. M. %A Pietrass, T. %A Budinger, T. F. %A Navon, G. %A Pines, A. %K gas %X

By means of optical pumping with laser light it is possible to enhance the nuclear spin polarization of gaseous xenon by four to five orders of magnitude, The enhanced polarization has allowed advances in nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), including polarization transfer to molecules and imaging of lungs and other void spaces, A critical issue for such applications is the delivery of xenon to the sample while maintaining the polarization, Described herein is an efficient method for the introduction of laser-polarized xenon into systems of biological and medical interest for the purpose of obtaining highly enhanced NMR/MRI signals. Using this method, we have made the first observation of the time-resolved process of xenon penetrating the red blood cells in fresh human blood-the xenon residence time constant in the red blood cells was measured to be 20.4+/-2 ms. The potential of certain biologically compatible solvents for delivery of laser-polarized xenon to tissues for NMR/MRI is discussed in light of their respective relaxation and partitioning properties.

%B Proceedings of the National Academy of Sciences of the United States of America %V 93 %P 12932-12936 %8 Nov 12 %@ 0027-8424 %G English %U ://WOS:A1996VT05400048 %N 23 %M WOS:A1996VT05400048 %! NMR of laser-polarized xenon in human blood %R Doi 10.1073/Pnas.93.23.12932