Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor

TitleMolecular imaging using a targeted magnetic resonance hyperpolarized biosensor
Publication TypeJournal Article
Year of Publication2006
AuthorsSchroder L., Lowery T.J, Hilty C., Wemmer D.E, Pines A
JournalScience
Volume314
Issue5798
Pagination446-449
Date PublishedOct 20
ISBN Number0036-8075
Accession NumberWOS:000241382500036
Keywordsagents
Abstract

A magnetic resonance approach is presented that enables high-sensitivity, high-contrast molecular imaging by exploiting xenon biosensors. These sensors link xenon atoms to specific biomolecular targets, coupling the high sensitivity of hyperpolarized nuclei with the specificity of biochemical interactions. We demonstrated spatial resolution of a specific target protein in vitro at micromolar concentration, with a readout scheme that reduces the required acquisition time by >3300-fold relative to direct detection. This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST). Because it is similar to 10,000 times more sensitive than previous CEST methods and other molecular magnetic resonance imaging techniques, it marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.

URL<Go to ISI>://WOS:000241382500036
DOI10.1126/Science.1131847
Short TitleMolecular imaging using a targeted magnetic resonance hyperpolarized biosensor
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