Sensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal

TitleSensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal
Publication TypeJournal Article
Year of Publication2007
AuthorsGarcia S., Chavez L., Lowery T.J, Han S.I, Wemmer D.E, Pines A
JournalJournal of Magnetic Resonance
Volume184
Issue1
Pagination72-77
Date PublishedJan
ISBN Number1090-7807
Accession NumberWOS:000243568900009
Keywordsresonance
Abstract

Hyperpolarized xenon associated with ligand derivatized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to 'remote detection' described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer and Fourier analysis of the bulk signal as a function of the evolution time. (c) 2006 Elsevier Inc. All rights reserved.

URL<Go to ISI>://WOS:000243568900009
DOI10.1016/J.Jmr.2006.09.010
Short TitleSensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal
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