Zero-Field NMR Enhanced by Parahydrogen in Reversible Exchange

TitleZero-Field NMR Enhanced by Parahydrogen in Reversible Exchange
Publication TypeJournal Article
Year of Publication2012
AuthorsTheis T., Ledbetter M.P, Kervern G., Blanchard J.W, Ganssle P.J, Butler M.C, Shin H.D, Budker D., Pines A
JournalJournal of the American Chemical Society
Date Published02/2012
ISBN Number0002-7863
Accession NumberWOS:000301550800015

We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP)(1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative para-hydrogen-induced polarization(4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 mu L, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.

URL<Go to ISI>://WOS:000301550800015
Short TitleZero-Field NMR Enhanced by Parahydrogen in Reversible Exchange
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