High-Resolution Zero-Field NMR J-Spectroscopy of Aromatic Compounds

TitleHigh-Resolution Zero-Field NMR J-Spectroscopy of Aromatic Compounds
Publication TypeJournal Article
Year of Publication2013
AuthorsBlanchard J.W, Ledbetter M.P, Theis T., Butler M.C, Budker D., Pines A
JournalJournal of the American Chemical Society
Volume135
Issue9
Pagination3607-3612
Date Published02/2013
ISBN Number0002-7863
Accession NumberWOS:000315936700050
Keywordsdensity
Abstract

We report the acquisition and interpretation of nuclear magnetic resonance (NMR) J-spectra at zero magnetic field for a series of benzene derivatives, demonstrating the analytical capabilities of zero-field NMR The zeroth-order spectral patterns do not overlap, which allows for straightforward determination of the spin interactions of substituent functional groups. Higher-order effects cause additional line splittings, revealing additional molecular information. We demonstrate resonance linewidths as narrow as 11 mHz, permitting resolution of minute frequency differences and precise determination of long-range J-couplings. The measurement of J-couplings with the high precision offered by zero-field NMR may allow further refinements in the determination of molecular structure and conformation.

URL<Go to ISI>://WOS:000315936700050
DOI10.1021/Ja312239v
Short TitleHigh-Resolution Zero-Field NMR J-Spectroscopy of Aromatic Compounds
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