Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

TitlePicomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
Publication TypeJournal Article
Year of Publication2009
AuthorsBouchard L.S, Anwar M.S, Liu G.L, Hann B., Xie Z.H, Gray J.W, Wang X.D, Pines A, Chen F.F
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue11
Pagination4085-4089
Date PublishedMar 17
ISBN Number0027-8424
Accession NumberWOS:000264278800008
Keywordscancer
Abstract

Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

URL<Go to ISI>://WOS:000264278800008
DOI10.1073/Pnas.0813019106
Short TitlePicomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles
Download Publication: