Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor

TitleRemote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor
Publication TypeJournal Article
Year of Publication2008
AuthorsVerpillat F., Ledbetter M.P, Xu S., Michalak D.J, Hilty C., Bouchard L.S, Antonijevic S., Budker D., Pines A
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue7
Pagination2271-2273
Date PublishedFeb 19
ISBN Number0027-8424
Accession NumberWOS:000253469900006
Keywordsmri
Abstract

We report the detection of nuclear magnetic resonance (NMR) using an anisotropic magnetoresistive (AMR) sensor. A "remote-detection" arrangement was used in which protons in flowing water were prepolarized in the field of a superconducting NMR magnet, adiabatically inverted, and subsequently detected with an AMR sensor situated downstream from the magnet and the adiabatic inverter. AMR sensing is well suited for NMR detection in microfluidic "lab-on-a-chip" applications because the sensors are small, typically on the order of 10 mu m. An estimate of the sensitivity for an optimized system indicates that approximate to 6 x 10(13) protons in a volume of 1,000 mu m(3), prepolarized in a 10-kG magnetic field, can be detected with a signal-to-noise ratio of 3 in a 1-Hz bandwidth. This level of sensitivity is competitive with that demonstrated by microcoils in superconducting magnets and with the projected sensitivity of microfabricated atomic magnetometers.

URL<Go to ISI>://WOS:000253469900006
DOI10.1073/Pnas.0712129105
Short TitleRemote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor
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