Optical detection of NMR J-spectra at zero magnetic field

TitleOptical detection of NMR J-spectra at zero magnetic field
Publication TypeJournal Article
Year of Publication2009
AuthorsLedbetter M.P, Crawford C.W, Pines A, Wemmer D.E, Knappe S., Kitching J., Budker D.
JournalJournal of Magnetic Resonance
Date PublishedJul
ISBN Number1090-7807
Accession NumberWOS:000266890300004

Scalar couplings of the form JI(1) . I(2) between nuclei impart valuable information about molecular structure to nuclear magnetic-resonance spectra. Here we demonstrate direct detection of J-spectra due to both heteronuclear and homonuclear J-coupling in a zero-field environment where the Zeeman interaction is completely absent. We show that characteristic functional groups exhibit distinct spectra with straightforward interpretation for chemical identification. Detection is performed with a microfabricated optical atomic magnetometer, providing high sensitivity to samples of microliter volumes. We obtain 0.1 Hz linewidths and measure scalar-coupling parameters with 4-mHz statistical uncertainty. We anticipate that the technique described here will provide a new modality for high-precision" J spectroscopy" using small samples oil microchip devices for multiplexed Screening, assaying, and sample identification in chemistry and biomedicine. (C) 2009 Elsevier Inc. All rights reserved.

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Short TitleOptical detection of NMR J-spectra at zero magnetic field
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