Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry

TitleRelaxivity of Gadolinium Complexes Detected by Atomic Magnetometry
Publication TypeJournal Article
Year of Publication2011
AuthorsMichalak D.J, Xu S.J, Lowery T.J, Crawford C.W, Ledbetter M., Bouchard L.S, Wemmer D.E, Budker D., Pines A
JournalMagnetic Resonance in Medicine
Date PublishedAug
ISBN Number0740-3194
Accession NumberWOS:000293256800033

Laser atomic magnetomeby is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 mu T). The measured relaxivity of 9.7 +/- 2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of similar to 10 mu M Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:605-608, 2011. (C) 2011 Wiley-Liss, Inc.

URL<Go to ISI>://WOS:000293256800033
Short TitleRelaxivity of Gadolinium Complexes Detected by Atomic Magnetometry
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